A Comparative Immunohistochemical Expression of Cyclin D1 in Keratocystic Odontogenic Tumor, Dentigerous and Radicular Cysts
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Abstract
Materials and Methods: In this study, thirty formalin fixed paraffin embedded tissue blocks of Odontogenic cysts and Tumor, consist of 14 Keratocystic Odontogenic Tumor, 8 dentigerous cysts and 8 radicular cysts were analyzed immunohistochemically for the presence of Cyclin D1 proteins.
Results: Strong to moderate expression of Cyclin D1 in epithelium was found in Keratocystic Odontogenic Tumor cases with positive cases percentage was (85.7%). Statistical significant differences (P<0.001) observed when comparing the three lesions. Immunoreactivity of Cyclin D1 in stroma of Keratocystic Odontogenic Tumor was higher than in dentigerous cysts and radicular cysts cases. However, the difference was not statistically significant (P<0.067).
Conclusion: The results of this study propose that high expression rate of Cyclin D1 might be one of the reasons for aggressive behavior of Keratocystic Odontogenic Tumor and high recurrence rate.
Key Words: Keratocystic Odontogenic Tumor, dentigerous cysts, radicular cysts, Cyclin D1, immunohistochemistry.
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