Serum and salivary levels of proinflammatory cytokines as potential biomarkers in the diagnosis of oral squamous cell carcinoma

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Nazar G Al Talabani
Shanaz M Gaphor
Abdul-Wahab R Hamad

Abstract

Background: Oral squamous cell carcinoma is one of the prevalent cancers of the body . If not treated at its early stages, the prognosis will be poor. Early diagnosis of oral cancer may not be easy clinically because of itsresemblance to a number of benign lesions in the mouth. The aim of the study was to evaluate the validity of measurement of some proinflammatory cytokines levels in serum and saliva asbiomarkers for early detection of oral cancer.
Materials and methods: The levels of Interleukins IL-1?, IIL-6, IL-8 and Granulocyte Macrophage-Colony Stimulating Factor (GM-CSF) in the serum and saliva of (30) patients with OSCC and (20) healthy (control) individuals weremeasured by enzyme linked immunosorbent assay (ELISA).
Results: Higher concentrations of serum IL-6 and IL-8 levels were observed in patients with OSCC than the control group (P<0.001). No significant difference was seen in serum IL-1 alpha and GM-CSF between patients with OSCC and control group. The levels of IL-1 alpha, IL-6, IL-8 and GM-CSF in saliva showed significant increase in patients with OSCC when compared with control group.
Conclusion: It is concluded that the levels of certain prinflammatory cytokines can be measured in serum and saliva of patients with OSCC and healthy individuals. Detection of increased levels of these elements can be used as biomarkers for early detection of oral cancer,

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How to Cite
Al Talabani , N., Gaphor , S. and Hamad , A.-W. (1) “Serum and salivary levels of proinflammatory cytokines as potential biomarkers in the diagnosis of oral squamous cell carcinoma”, Journal of Baghdad College of Dentistry, 21(1), pp. 60-65. Available at: http://jbcd.uobaghdad.edu.iq/index.php/jbcd/article/view/115 (Accessed: 29February2020).
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