Immunohistochemical Expressions of AKT, ATM and Cyclin E in Oral Squamous Cell Carcinoma
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Abstract
Materials and methods: This study was performed on a forty formalin-fixed paraffin-embedded blocks which histopathologically diagnosed as Oral Squamous Cell Carcinoma. All cases were collected from the Histopathological Laboratory from patients treated surgically at Maxillofacial surgery Department at Ramadi Teaching Hospital, Iraq.
Results: The immunohistochemical staining of AKT showed positive expression in 38 (95%), ATM showed positive expression in 38(95%) and Cyclin E showed positive expression in 36(90%) of the cases.
Conclusion: A statically significant correlation was found regarding the immunohistochemical expression of AKT with tumor grade and stage, Cyclin E with the age group and ATM with the clinical appearance
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