Immunohistochemical Expressions of AKT, ATM and Cyclin E in Oral Squamous Cell Carcinoma

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Published: Sep 14, 2016

DOI: https://doi.org/10.12816/0031107

Afrah A. Khalil

Seta A. Sarkis

Abstract

Background: Understanding the pathogenesis and molecular basis of Oral Squamous Cell Carcinoma (OSCC) has increased rapidly over the past few years that is essential to improve patient's prognosis and treatment modalities. The purpose of this study to evaluate the Immunohistochemical expressions of AKT, ATM, AND Cyclin E in oral squamous cell carcinoma
Materials and methods: This study was performed on a forty formalin-fixed paraffin-embedded blocks which histopathologically diagnosed as Oral Squamous Cell Carcinoma. All cases were collected from the Histopathological Laboratory from patients treated surgically at Maxillofacial surgery Department at Ramadi Teaching Hospital, Iraq.
Results: The immunohistochemical staining of AKT showed positive expression in 38 (95%), ATM showed positive expression in 38(95%) and Cyclin E showed positive expression in 36(90%) of the cases.
Conclusion: A statically significant correlation was found regarding the immunohistochemical expression of AKT with tumor grade and stage, Cyclin E with the age group and ATM with the clinical appearance

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How to Cite

Khalil AA, Sarkis SA. Immunohistochemical Expressions of AKT, ATM and Cyclin E in Oral Squamous Cell Carcinoma. J Bagh Coll Dent [Internet]. 2016 Sep. 14 [cited 2024 Dec. 19];28(3):44-51. Available from: https://jbcd.uobaghdad.edu.iq/index.php/jbcd/article/view/1424

Issue

Vol. 28 No. 3 (2016)

Section

Oral Diagnosis

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