Immunohistochemical study of PDGF, IGF of radiated tooth rat embryo
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Abstract
Materials and Methods: Animal model: Thirty-six female rats were used in this study .Starting from zero days (time of gestation that recorded) the pregnant rats were divided into three groups. Group A serve as a control, groups B exposed to microwave oven radiation For (15 /minutes; 5/min /hour for 3 hours continuously) daily and C exposed to EMF radiation for (45 minutes ;15 min /hour for3hours continuously)daily starting from zero day of gestation till the last day. The embryo of rats at 16thday and 18th day of intrauterine life and one day old rat (new born rat) were studied immunohistochemically for localized of platelet derived growth factor (PDGF) and insulin growth factor (IGF) markers.
Results:The results showed that experimental group (B) exposed to short duration of radiation (5/ min.) stimulates the development of tooth germ and faster tooth growing in comparison to control with immunohistochemical results show strong to moderate intense stain for positive expression of growth factors(PDGF,IGF) by dental tissue.For long exposure period of radiation( group C) , it showed retardation in the tooth growth withimmunohistochemical findings record weak to negative intense stain for the expression of growth factors(PDGF,IGF) by dental tissue.
Conclusion: Exposure to microwave (oven) radiation during pregnancy may play a role in the expression of IGF and PDGF by cells of tooth germ thatinfluence on cell differentiation and physiological activity of specialized dental cells, depending on exposure time.
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