Salivary irisin in relation to recurrent aphthous ulcerand weight status in Diyala city/Iraq
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Abstract
Background: Recurrent aphthous stomatitis remains the most common ulcerative disease of the oral mucosa that exists as painfull round shallow ulcers with a well-defined erythematous margin and a yellowish grey pseudomembranous centre. Salivary irisin is an identified adipomyokine and research has revealed that it has an anti-inflammatory effect and is a novel myokine; it is synthesized in skeletal muscle and adipose tissue. The aim of the present study was to evaluate the relation of salivary irisin to recurrent aphthous ulcers and weight status in Diyala City / Iraq. Materials and methods: A cross-sectional comparative study was carried out during the period from the end of December (2021) until the end of March (2022). The total sample size composed of all patients attending a specialised dental center in Ba’aquba / Diyala governorate with recurrent aphthous ulcers of both gender and ages ranged from 20-30 years (100 patients consider the study group) assessed according to the directions suggested by the WHO (1997) and compared to the control group free from this lesion (100 patients consider the control group) matching in age and sex. The weight status was assessed using the digital weight scale. The sub samples of 45 from each study and the control group were selected to analyse salivary irisin. The description of data, presentation, and analysis process is carried out through the use of the SPSS package (SPSS version 22, Chicago, Illinois, USA). For the quantitative variable mean, the standard deviation (SD) was used. Frequency and percentage are used for the qualitative variable. The independent sample T test was used for the difference between the two groups. Pearson’s correlation was used for the linear correlation between two quantitative variables. Results: The highest percentage of recurrent aphthous ulcer was found in the lower lip. The mean value of irisin was higher among the study group than in the control group. The mean value of the body mass index among the control group was higher than that of the study group. When correlating the body mass index with salivary irisin, it is a positive weak not significant correlation. Conclusions: This study concluded that there is an elevated level of irisin among recurrent aphthous ulcers, in addition to that, the recurrent aphthous ulcer decreases the body mass index.
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References
Akintoye SO, Greenberg MS. Recurrent aphthous stomatitis. Dent Clin North Am. 2014;58(2):281-297.
Jurge S, Kuffer R, Scully C, Porter SR. Mucosal disease series. Number VI. Recurrent aphthous stomatitis. Oral Dis. 2006;12(1):1-21.
Edgar NR, Saleh D, Miller RA. Recurrent Aphthous Stomatitis: A Review. J Clin Aesthet Dermatol. 2017; 10(3):26-36.
Douglas C. Treaty of applied physiology speech therapy. São Paulo: Robe Editorial. 2002.
Dodds MW, Johnson DA, Yeh CK. Health benefits of saliva: a review. J Dent. 2005;33(3):223-233.
Altay DU, Korkmaz M, Ergun S, Korkmaz H, Noyan T. Salivary irisin: potential inflammatory biomarker in recurrent apthous stomatitis patients. Eur Rev Med Pharmacol Sci. 2021;25(5):2252-2259.
Boström P, Wu J, Jedrychowski MP, Korde A, Ye L, Lo JC, et al. A PGC1-α-dependent myokine that drives brown-fat-like development of white fat and thermogenesis. Nature. 2012;481(7382):463-468.
Arhire LI, Mihalache L, Covasa M. Irisin: A Hope in Understanding and Managing Obesity and Metabolic Syndrome. Front Endocrinol (Lausanne). 2019; 10:524.
Roca-Rivada A, Castelao C, Senin LL, Landrove MO, Baltar J, Crujeiras AB, et al. FNDC5/irisin is not only a myokine but also an adipokine. PLoS One. 2013; 8(4):e60563.
Bilski J, Mazur-Bialy AI, Brzozowski B, Magierowski M, Jasnos K, Krzysiek-Maczka G, Urbanczyk K, et al. Moderate exercise training attenuates the severity of experimental rodent colitis: the importance of crosstalk between adipose tissue and skeletal muscles. Mediators Inflamm. 2015; 2015:605071.
Bakal U, Aydin S, Sarac M, Kuloglu T, Kalayci M, Artas G, et al. Serum, Saliva, and Urine Irisin with and Without Acute Appendicitis and Abdominal Pain. Biochem Insights. 2016;9:11-17.
Askari H, Rajani SF, Poorebrahim M, Haghi-Aminjan H, Raeis-Abdollahi E, Abdollahi M. A glance at the therapeutic potential of irisin against diseases involving inflammation, oxidative stress, and apoptosis: An introductory review. Pharmacol Res. 2018;129:44-55.
Mazur-Bialy AI, Pocheć E, Zarawski M. Anti-Inflammatory Properties of Irisin, Mediator of Physical Activity, Are Connected with TLR4/MyD88 Signaling Pathway Activation. Int J Mol Sci. 2017;18(4):701. Published 2017 Mar 25.
Shahidi S, Hejazi J, Moghimi M, Borji S, Zabihian S, Fathi M. Circulating Irisin Levels and Redox Status Markers in Patients with Gastric Cancer: A Case-Control Study. Asian Pac J Cancer Prev. 2020; 21(10):2847-2851. Published 2020 Oct 1.
Physical status: the use and interpretation of anthropometry. Report of a WHO Expert Committee. World Health Organ Tech Rep Ser. 1995; 854:1-452.
Huh JY, Panagiotou G, Mougios V, Brinkoetter M, Vamvini MT, Schneider BE, et al. FNDC5 and irisin in humans: I. Predictors of circulating concentrations in serum and plasma and II. mRNA expression and circulating concentrations in response to weight loss and exercise. Metabolism. 2012;61(12):1725-1738.
Liu JJ, Wong MD, Toy WC, Tan CS, Liu S, Ng XW, et al. Lower circulating irisin is associated with type 2 diabetes mellitus. J Diabetes Complications. 2013; 27(4):365-369.
Stengel A, Hofmann T, Goebel-Stengel M, Elbelt U, Kobelt P, Klapp BF. Circulating levels of irisin in patients with anorexia nervosa and different stages of obesity--correlation with body mass index. Peptides. 2013; 39:125-130.
Moreno-Navarrete JM, Ortega F, Serrano M, Guerra E, Pardo G, Tinahones F, et al. Irisin is expressed and produced by human muscle and adipose tissue in association with obesity and insulin resistance. J Clin Endocrinol Metab. 2013; 98(4):E769-E778.
Choi YK, Kim MK, Bae KH, Seo HA, Jeong JY, Lee WK, et al. Serum irisin levels in new-onset type 2 diabetes. Diabetes Res Clin Pract. 2013; 100(1):96-101.
Schooling CM, Lam TH, Li ZB, Ho SY, Chan WM, Ho KS, et al. Obesity, physical activity, and mortality in a prospective chinese elderly cohort. Arch Intern Med. 2006;166(14):1498-1504.
Kahn HS, Bullard KM, Barker LE, Imperatore G. Differences between adiposity indicators for predicting all-cause mortality in a representative sample of United States non-elderly adults. PLoS One. 2012; 7(11):e50428.
Munro CL, Grap MJ, Jablonski R, Boyle A. Oral health measurement in nursing research: state of the science. Biol Res Nurs. 2006; 8(1):35-42.
Schipper RG, Silletti E, Vingerhoeds MH. Saliva as research material: biochemical, physicochemical and practical aspects. Arch Oral Biol. 2007; 52(12):1114-1135.
Organization WH, Oral health surveys-Basic methods, 4th edition, Geneva, 1997.
Organization WH, The management of nutrition in major emergencies, Geneva, 2000.
Center for Disease Control and Prevention (CDC). Growth Chart, United States, National Center for Health Statistic in collaboration with National Center for Chronic Disease Prevention and Health Promotion, 2000.
Queiroz SIML, Silva MVAD, Medeiros AMC, Oliveira PT, Gurgel BCV, Silveira ÉJDD. Recurrent aphthous ulceration: an epidemiological study of etiological factors, treatment and differential diagnosis. An Bras Dermatol. 2018; 93(3):341-346.
Chattopadhyay A, Chatterjee S. Risk indicators for recurrent aphthous ulcers among adults in the US. Community Dent Oral Epidemiol. 2007; 35(2):152-159.
Oyetola EO, Mogaji IK, Agho TO, Ayilara OA. Pattern of Presentation of Oral Ulcerations in Patients Attending an Oral Medicine Clinic in Nigeria. Ann Ib Postgrad Med. 2018;16(1):9-11.
Safadi RA. Prevalence of recurrent aphthous ulceration in Jordanian dental patients. BMC Oral Health. 2009; 9:31. Published 2009 Nov 22.