In vivo immunohistochemical investigation of the effect of the topical application of growth hormone on the osseointegration of cpTi implant
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Abstract
Materials and Methods: Eighty titanium screw implants were inserted in the tibia of the forty adult rabbits. Growth hormone was applied on experimental implants. Immunohistochemical tests were performed on the implants of both control and experimental groups for (3 days1, 2, and 6 weeks) healing intervals.
Results: Titanium implants coated with growth hormone revealed an early bone formation, minerlization and maturation in comparison to control. Immunohistochemical findings revealed positive expression for VEGF in experimental implant in comparison to control one.
Conclusion: Topical application of growth hormone may act as a bone stimulant in the placement of endosseous dental implants and enhances osseointegration.
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