Immunohistochemical expression of HOXA1, and Ki-67 proteins of oral squamous cell carcinoma
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Abstract
Materials and Methods: Thirty formalin-fixed, paraffin- embedded tissue blocks of oral squamous cell carcinoma were included in this study. H&E stain was done for each block for reassessment of histological examination. An immunohistochimical stain was performed using anti HOXA1 and anti Ki-67 poly clonal antibodies.
Results:The expression of HOXA1 and Ki-67were positive in all oral squamous cell carcinoma cases & in all layers (100%), while the expression was restricted to the basal and supra basal layer in normal oral mucosa. Statistically non-significant correlation observed between each marker with clinico-pathological parameters. While a statistically significant association was found between the expressions of two markers, (p-value= 0.027).
Conclusion: The statistically significant association observed between expressions of HOXA1 with the specific marker of proliferation Ki-67. This suggested important role in oral SCC development and progression.
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