Immunohistochemical expression of MMP1 and TIMP1 as markers of migration in Hodgkin’s and non-Hodgkin’s lymphoma of the head and neck region (A comparative study)

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Zaydoon M Kasim
Wasan H Younis

Abstract

Background: Malignant lymphoma is a term that describes primary tumors of the lymphoreticular system, almost all of which arise from lymphocytes.MMP-1 is the most ubiquitously expressed interstitial collagenase, a subfamily of MMPs that cleaves stromal collagens. It is also called collagenase-1.TIMPs which inhibits MMP activity and thereby restrict extracellular matrix breakdown, TIMP-1 is a stromal factor that has a wide spectrum of functions in different tissues.
Material and Methods: This study was performed on (68) formalin-fixed, paraffin-embedded blocks, histopathologically diagnosed as lymphoma (head and neck lesions). Immunohistochemical staining of MMP1and TIMP1 was performed on each case of the study sample.
Results: The expression of MMP1was cytoplasmic, the study cases showed a 98.5% positive reaction to MMP1, score 3 was the most common and found in 60.3% of all cases.The expression of TIMP1was cytoplasmic, 92.6% of cases expressed positive reactions to TIMP1, score 1 was the most common and found in 57.4% of all cases.
Conclusion: This study showed for the first time the effect of MMP-1 in HL, which is considered to be as an invasive and migratory cell marker. A significant difference was found among the subtypes of NHL in relation to TIMP1, TIMP1inhibits the effect of MMP1 and as MMP1 is elevated the TIMP1 will be elevated too.

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How to Cite
1.
Kasim ZM, Younis WH. Immunohistochemical expression of MMP1 and TIMP1 as markers of migration in Hodgkin’s and non-Hodgkin’s lymphoma of the head and neck region (A comparative study) . J Bagh Coll Dent [Internet]. 2014 Sep. 15 [cited 2024 Mar. 28];26(3):72-8. Available from: https://jbcd.uobaghdad.edu.iq/index.php/jbcd/article/view/520
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Oral Diagnosis

How to Cite

1.
Kasim ZM, Younis WH. Immunohistochemical expression of MMP1 and TIMP1 as markers of migration in Hodgkin’s and non-Hodgkin’s lymphoma of the head and neck region (A comparative study) . J Bagh Coll Dent [Internet]. 2014 Sep. 15 [cited 2024 Mar. 28];26(3):72-8. Available from: https://jbcd.uobaghdad.edu.iq/index.php/jbcd/article/view/520

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