Potential of Salivary Matrix Metalloproteinase 9 to Discriminate Periodontal health and disease
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Abstract
Periodontitis is a chronic inflammatory disease resulted from aggravated immune response to a dysbiotic subgingival microbiota of a susceptible host. Consequences of periodontitis are not only limited to the devastating effect on the oral cavity but extends to affect general health of the individual and also exerts economic burdens on the health systems worldwide. Despite these serious outcomes of periodontitis; however, they are avoidable by early diagnosis with proper preventive measures or non-invasive interventions at earlier stages of the disease. Clinically, diagnosis of periodontitis could be overlooked due to certain limitations of the conventional diagnostic methods such as periodontal charting and radiographs. Utilization of readily available biomarkers in the oral biofluids represents a potential opportunity to overcome these issues. This topic received great attention in the last decades and one of these biomarkers is matrix metalloproteinase 9 which is highlighted in this review as one of the candidates that can be used for diagnosis of periodontal diseases
Received date: 15-3-2022
Accepted date: 14-5-2022
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References
Kinane DF, Stathopoulou PG and Papapanou PN. Periodontal diseases. Nat Rev Dis Primers. 2017;3:17038. DOI: https://doi.org/10.1038/nrdp.2017.38
Botelho J, Machado V, Leira Y, Proença L, Chambrone L and Mendes JJ. Economic burden of periodontitis in the United States and Europe: An updated estimation. J Periodontol. 2022;93:373-379. DOI: https://doi.org/10.1002/JPER.21-0111
Kornman KS. Mapping the pathogenesis of periodontitis: a new look. J Periodontol. 2008;79:1560-8. DOI: https://doi.org/10.1902/jop.2008.080213
Nazir M, Al-Ansari A, Al-Khalifa K, Alhareky M, Gaffar B and Almas K. Global Prevalence of Periodontal Disease and Lack of Its Surveillance. ScientificWorldJournal. 2020;2020:2146160. DOI: https://doi.org/10.1155/2020/2146160
Darveau RP. Periodontitis: a polymicrobial disruption of host homeostasis. Nat Rev Microbiol. 2010;8:481-90. DOI: https://doi.org/10.1038/nrmicro2337
Offenbacher S. Periodontal diseases: pathogenesis. Ann Periodontol. 1996;1:821-78. DOI: https://doi.org/10.1902/annals.1996.1.1.821
Weng H, Yan Y, Jin YH, Meng XY, Mo YY and Zeng XT. Matrix metalloproteinase gene polymorphisms and periodontitis susceptibility: a meta-analysis involving 6,162 individuals. Sci Rep. 2016;6:24812. DOI: https://doi.org/10.1038/srep24812
Romanos GE and Bernimoulin JP. [Collagen as a basic element of the periodontium: immunohistochemical aspects in the human and animal. 1. Gingiva and alveolar bone]. Parodontol. 1990;1:363-75.
Murphy G. Tissue inhibitors of metalloproteinases. Genome Biol. 2011;12:233. DOI: https://doi.org/10.1186/gb-2011-12-11-233
Checchi V, Maravic T, Bellini P, Generali L, Consolo U, Breschi L and Mazzoni A. The Role of Matrix Metalloproteinases in Periodontal Disease. Int J Environ Res Public Health. 2020;17. DOI: https://doi.org/10.3390/ijerph17144923
Caton JG, Armitage G, Berglundh T, Chapple ILC, Jepsen S, Kornman KS, Mealey BL, Papapanou PN, Sanz M and Tonetti MS. A new classification scheme for periodontal and peri-implant diseases and conditions - Introduction and key changes from the 1999 classification. J Periodontol. 2018;89 Suppl 1:S1-s8. DOI: https://doi.org/10.1002/JPER.18-0157
Slots J. Periodontitis: facts, fallacies and the future. Periodontol 2000. 2017;75:7-23. DOI: https://doi.org/10.1111/prd.12221
Andrade R, Espinoza M, Gómez EM, Espinoza JR and Cruz E. Intra- and inter-examiner reproducibility of manual probing depth. Braz Oral Res. 2012;26:57-63. DOI: https://doi.org/10.1590/S1806-83242012000100010
Lafzi A, Mohammadi AS, Eskandari A and Pourkhamneh S. Assessment of Intra- and Inter-examiner Reproducibility of Probing Depth Measurements with a Manual Periodontal Probe. J Dent Res Dent Clin Dent Prospects. 2007;1:19-25.
Papapanou PN, Sanz M, Buduneli N, Dietrich T, Feres M, Fine DH, Flemmig TF, Garcia R, Giannobile WV, Graziani F, Greenwell H, Herrera D, Kao RT, Kebschull M, Kinane DF, Kirkwood KL, Kocher T, Kornman KS, Kumar PS, Loos BG, Machtei E, Meng H, Mombelli A, Needleman I, Offenbacher S, Seymour GJ, Teles R and Tonetti MS. Periodontitis: Consensus report of workgroup 2 of the 2017 World Workshop on the Classification of Periodontal and Peri-Implant Diseases and Conditions. J Periodontol. 2018;89 Suppl 1:S173-s182. DOI: https://doi.org/10.1002/JPER.17-0721
Shaddox LM and Walker CB. Treating chronic periodontitis: current status, challenges, and future directions. Clin Cosmet Investig Dent. 2010;2:79-91. DOI: https://doi.org/10.2147/CCIDE.S7712
Kim HD, Sukhbaatar M, Shin M, Ahn YB and Yoo WS. Validation of periodontitis screening model using sociodemographic, systemic, and molecular information in a Korean population. J Periodontol. 2014;85:1676-83. DOI: https://doi.org/10.1902/jop.2014.140061
Chen Q, Jin M, Yang F, Zhu J, Xiao Q and Zhang L. Matrix metalloproteinases: inflammatory regulators of cell behaviors in vascular formation and remodeling. Mediators Inflamm. 2013;2013:928315. DOI: https://doi.org/10.1155/2013/928315
Jotwani R, Eswaran SV, Moonga S and Cutler CW. MMP-9/TIMP-1 imbalance induced in human dendritic cells by Porphyromonas gingivalis. FEMS Immunol Med Microbiol. 2010;58:314-21. DOI: https://doi.org/10.1111/j.1574-695X.2009.00637.x
Xie R, Kuijpers-Jagtman AM and Maltha JC. Osteoclast differentiation and recruitment during early stages of experimental tooth movement in rats. Eur J Oral Sci. 2009;117:43-50. DOI: https://doi.org/10.1111/j.1600-0722.2008.00588.x
Somerville RP, Oblander SA and Apte SS. Matrix metalloproteinases: old dogs with new tricks. Genome Biol. 2003;4:216. DOI: https://doi.org/10.1186/gb-2003-4-6-216
Delaissé JM, Andersen TL, Engsig MT, Henriksen K, Troen T and Blavier L. Matrix metalloproteinases (MMP) and cathepsin K contribute differently to osteoclastic activities. Microsc Res Tech. 2003;61:504-13. DOI: https://doi.org/10.1002/jemt.10374
Şurlin P, Oprea B, Solomon SM, Popa SG, Moţa M, Mateescu GO, Rauten AM, Popescu DM, Dragomir LP, Puiu I, Bogdan M and Popescu MR. Matrix metalloproteinase -7, -8, -9 and -13 in gingival tissue of patients with type 1 diabetes and periodontitis. Rom J Morphol Embryol. 2014;55:1137-41.
Kc S, Wang XZ and Gallagher JE. Diagnostic sensitivity and specificity of host-derived salivary biomarkers in periodontal disease amongst adults: Systematic review. J Clin Periodontol. 2020;47:289-308. DOI: https://doi.org/10.1111/jcpe.13218
de Morais EF, Pinheiro JC, Leite RB, Santos PPA, Barboza CAG and Freitas RA. Matrix metalloproteinase-8 levels in periodontal disease patients: A systematic review. J Periodontal Res. 2018;53:156-163. DOI: https://doi.org/10.1111/jre.12495
Victor DJ, Subramanian S, Gnana PP and Kolagani SP. Assessment of Matrix Metalloproteinases-8 and -9 in Gingival Crevicular Fluid of Smokers and Non-smokers with Chronic Periodontitis Using ELISA. J Int Oral Health. 2014;6:67-71.
Saglam M, Kantarci A, Dundar N and Hakki SS. Clinical and biochemical effects of diode laser as an adjunct to nonsurgical treatment of chronic periodontitis: a randomized, controlled clinical trial. Lasers Med Sci. 2014;29:37-46. DOI: https://doi.org/10.1007/s10103-012-1230-0
Bostanci N, Mitsakakis K, Afacan B, Bao K, Johannsen B, Baumgartner D, Müller L, Kotolová H, Emingil G and Karpíšek M. Validation and verification of predictive salivary biomarkers for oral health. Sci Rep. 2021;11:6406. DOI: https://doi.org/10.1038/s41598-021-85120-w
Kim H-D, Lee C-S, Cho H-J, Jeon S, Choi Y-N, Kim S, Kim D, Jin Lee H, Vu H, Jeong H-J and Kim B. Diagnostic ability of salivary matrix metalloproteinase-9 lateral flow test point-of-care test for periodontitis. J Clin Periodontol. 2020;47:1354-1361. DOI: https://doi.org/10.1111/jcpe.13360
Kim. HD, Kim S, Jeon S, Kim SJ, Cho HJ and Choi YN. Diagnostic and Prognostic ability of salivary MMP-9 and S100A8 for periodontitis. J Clin Periodontol. 2020;47:1191-1200. DOI: https://doi.org/10.1111/jcpe.13349
Alassiri S, Parnanen P, Rathnayake N, Johannsen G, Heikkinen AM, Lazzara R, van der Schoor P, van der Schoor JG, Tervahartiala T, Gieselmann D and Sorsa T. The Ability of Quantitative, Specific, and Sensitive Point-of-Care/Chair-Side Oral Fluid Immunotests for aMMP-8 to Detect Periodontal and Peri-Implant Diseases. Dis Markers. 2018;2018:1306396. DOI: https://doi.org/10.1155/2018/1306396