A clinicopathological analysis of 151 odontogenic tumors based on new WHO classification 2022: A retrospective cross-sectional study
Main Article Content
Abstract
Background: Odontogenic tumors are a diverse group of lesions with a variety of clinical behavior and histopathologic subtypes, from hamartomatous and benign to malignant. The study aimed to examine the clinical and pathological features of odontogenic tumors in Baghdad over the last 11 years (2011–2021). Materials and Methods: The present retrospective study analyzed all formalin-fixed, paraffin-embedded tissue blocks of patients diagnosed with an odontogenic tumor that were retrieved from archives at a teaching hospital/College of Dentistry in Baghdad University, Iraq, between 2011 and 2021. The diagnosis of each case was confirmed by examining the hematoxylin and eosin stained sections by two expert pathologists. Data from patients' case sheets were collected, including age, gender, location, and histopathological information. The type of lesions was evaluated based on the World Health Organization's most recent classification (March 2022). Results: There were 151 odontogenic tumor during this period. The most common type (39.1%) was Solid ameloblastoma. The mandibular tumors (76.8%) were more than the maxillary tumors (23.2%). The female to male ratio was 1.1:1. The most cases are found between the 2nd and 5th decades of life. Conclusions: Solid ameloblastoma was the most common odontogenic tumor, while primordial odontogenic tumor was the rarest, Odontogenic tumors were slightly more common in females than in males, the most common cases occur in the mandible., the outcome of the study gives valuable information regarding the patients' profile and type of odontogenic tumors over 11 years, which could aid in the early diagnosis and enhance the intervention.
Received date: 10-09-2022
Accepted date: 01-12-2022
Published date:15-03-2024
Downloads
Article Details
This work is licensed under a Creative Commons Attribution 4.0 International License.
Licenses and Copyright
The following policy applies in The Journal of Baghdad College of Dentistry (JBCD):
# JBCD applies the Creative Commons Attribution (CC BY) license to articles and other works we publish. If you submit your paper for publication by JBCD, you agree to have the CC BY license applied to your work. Under this Open Access license, you as the author agree that anyone can reuse your article in whole or part for any purpose, for free, even for commercial purposes. Anyone may copy, distribute, or reuse the content as long as the author and original source are properly cited. This facilitates freedom in re-use and also ensures that JBCD content can be mined without barriers for the needs of research.
# If your manuscript contains content such as photos, images, figures, tables, audio files, videos, etc., that you or your co-authors do not own, we will require you to provide us with proof that the owner of that content (a) has given you written permission to use it, and (b) has approved of the CC BY license being applied to their content. We provide a form you can use to ask for and obtain permission from the owner. If you do not have owner permission, we will ask you to remove that content and/or replace it with other content that you own or have such permission to use.Don't assume that you can use any content you find on the Internet, or that the content is fair game just because it isn't clear who the owner is or what license applies.
# Many authors assume that if they previously published a paper through another publisher, they own the rights to that content and they can freely use that content in their paper, but that’s not necessarily the case, it depends on the license that covers the other paper. Some publishers allow free and unrestricted re-use of article content they own, such as under the CC BY license. Other publishers use licenses that allow re-use only if the same license is applied by the person or publisher re-using the content. If the paper was published under a CC BY license or another license that allows free and unrestricted use, you may use the content in your JBCD paper provided that you give proper attribution, as explained above.If the content was published under a more restrictive license, you must ascertain what rights you have under that license. At a minimum, review the license to make sure you can use the content. Contact that JBCD if you have any questions about the license. If the license does not permit you to use the content in a paper that will be covered by an unrestricted license, you must obtain written permission from the publisher to use the content in your JBCD paper. Please do not include any content in your JBCD paper which you do not have rights to use, and always give proper attribution.
# If any relevant accompanying data is submitted to repositories with stated licensing policies, the policies should not be more restrictive than CC BY.
# JBCD reserves the right to remove any photos, captures, images, figures, tables, illustrations, audio and video files, and the like, from any paper, whether before or after publication, if we have reason to believe that the content was included in your paper without permission from the owner of the content.
How to Cite
Publication Dates
References
Akay MC, Zeytinoğlu M, Şimşek B, Aras I. Multidisciplinary management of benign jaw tumors in children. A Textbook of Advanced Oral and Maxillofacial Surgery. Vol. 2. IntechOpen; 2015. DOI: https://doi.org/10.5772/59341
Wright JM, Tekkesin MS. Odontogenic tumors: where are we in 2017? Journal of Istanbul University Faculty of Dentistry. 2017;51(3). DOI: https://doi.org/10.17096/jiufd.52886
Sivapathasundharam B, Biswas PG, Preethi S. The World Health Organization classification of odontogenic and maxillofacial bone tumors: An appraisal. Journal of oral maxillofacial pathology. JOMFP. 2019;23(2). DOI: https://doi.org/10.4103/jomfp.JOMFP_211_19
Vered M, Wright JM. Update from the 5th edition of the World Health Organization classification of Head and neck tumors: Odontogenic and Maxillofacial Bone Tumours. Head Neck Pathol [Internet]. 2022;16(1):63–75. DOI: https://doi.org/10.1007/s12105-021-01404-7
Rajendra Santosh AB, Ogle OE. Odontogenic tumors. Dent Clin North Am 2020; 64:121–138. DOI: https://doi.org/10.1016/j.cden.2019.08.008
Richardson MS, Muller S. Malignant odontogenic tumors: an update on selected tumors. Head Neck Pathol [Internet]. 2014;8(4):411–20. DOI: https://doi.org/10.1007/s12105-014-0584-y
Avelar RL, Primo BT, Pinheiro-Nogueira CB, Studart-Soares EC, de Oliveira RB, Romulo de Medeiros J, et al. Worldwide incidence of odontogenic tumors. J Craniofac Surg [Internet]. 2011;22(6):2118–23. DOI: https://doi.org/10.1097/SCS.0b013e3182323cc7
Da Silva LP, De Paiva Macedo RA, Serpa MS, Sobral A, De Souza LB. Global frequency of benign and malignant odontogenic tumors according to the 2005 WHO classification. Journal of Oral Diagnosis. 2017;2(1):1–8. DOI: https://doi.org/10.5935/2525-5711.20170044
Aborisade A, Akinyele A, Aregbesola B, Adesina O, Ladeji A. Immunohistochemical expression of E-cadherin, N-cadherin and Snail/slug in ameloblastoma. J Stomatol Oral Maxillofac Surg [Internet]. 2022;123(6):e801–7. DOI: https://doi.org/10.1016/j.jormas.2022.05.026
Mosqueda-Taylor A, Ledesma-Montes C, Caballero-Sandoval S, Portilla-Robertson J, Ruíz-Godoy Rivera LM, Meneses-García A. Odontogenic tumors in Mexico: a collaborative retrospective study of 349 cases. Oral Surg Oral Med Oral Pathol Oral Radiol Endod [Internet]. 1997;84(6):672–5. DOI: https://doi.org/10.1016/S1079-2104(97)90371-1
Nalabolu GRK, Mohiddin A, Hiremath SKS, Manyam R, Bharath TS, Raju PR. Epidemiological study of odontogenic tumours: An institutional experience. J Infect Public Health [Internet]. 2017;10(3):324–30. DOI: https://doi.org/10.1016/j.jiph.2016.05.014
Servato JPS, Prieto-Oliveira P, de Faria PR, Loyola AM, Cardoso SV. Odontogenic tumours: 240 cases diagnosed over 31 years at a Brazilian university and a review of international literature. Int J Oral Maxillofac Surg [Internet]. 2013;42(2):288–93. DOI: https://doi.org/10.1016/j.ijom.2012.05.008
Varkhede A, Tupkari JV, Mandale MS, Sardar M. Odontogenic tumors: a review of 60 cases. J Clin Exp Dent [Internet]. 2010;e183–6. DOI: https://doi.org/10.4317/jced.2.e183
Goteti SH. Odontogenic tumors: A review of 675 cases in eastern Libya. Niger J Surg [Internet]. 2016;22(1):37–40. DOI: https://doi.org/10.4103/1117-6806.176397
Sekerci A-E, Nazlim S, Etoz M, Deniz K, Yasa Y. Odontogenic tumors: a collaborative study of 218 cases diagnosed over 12 years and comprehensive review of the literature. Med Oral Patol Oral Cir Bucal [Internet]. 2015;20(1):e34-44. DOI: https://doi.org/10.4317/medoral.19157
Mascitti M, Togni L, Troiano G, Caponio VCA, Sabatucci A, Balercia A, et al. Odontogenic tumours: a 25-year epidemiological study in the Marche region of Italy. Eur Arch Otorhinolaryngol [Internet]. 2020;277(2):527–38. DOI: https://doi.org/10.1007/s00405-019-05683-3
Gdo R, Porto JC, Vieira D, Siqueira FM, Rivero E. Odontogenic tumors: a 14-year retrospective study in Santa Catarina, Brazil. Brazilian oral research. 2013;28:33–8. DOI: https://doi.org/10.1590/S1806-83242013005000030
El-Gehani R, Orafi M, Elarbi M, Subhashraj K. Benign tumours of orofacial region at Benghazi, Libya: a study of 405 cases. J Craniomaxillofac Surg [Internet]. 2009;37(7):370–5. DOI: https://doi.org/10.1016/j.jcms.2009.02.003
de Medeiros W-K-D, da Silva L-P, Santos P-P-A, Pinto L-P, de Souza L-B. Clinicopathological analysis of odontogenic tumors over 22 years period: Experience of a single center in northeastern Brazil. Med Oral Patol Oral Cir Bucal [Internet]. 2018;23(6):e664–71. DOI: https://doi.org/10.4317/medoral.22618
Kebede B, Tare D, Bogale B, Alemseged F. Odontogenic tumors in Ethiopia: eight years retrospective study. BMC Oral Health [Internet]. 2017;17(1). DOI: https://doi.org/10.1186/s12903-017-0347-8
Taghavi N, Rajabi M, Mehrdad L, Sajjadi S. A 10-year retrospective study on odontogenic tumors in Iran. Indian J Dent Res [Internet]. 2013;24(2):220–4. DOI: https://doi.org/10.4103/0970-9290.116688
Monteiro LS, Martins M, Pacheco JJ, Salazar F, Magalhães J, Vescovi P. Er: YAG Laser assisted treatment of central odontogenic fibroma of the mandible. Case Reports in Dentistry. 2015. DOI: https://doi.org/10.1155/2015/230297
Mosqueda-Taylor A, Martínez-Mata G, Carlos-Bregni R, Vargas PA, Toral-Rizo V, Cano-Valdéz AM, et al. Central odontogenic fibroma: new findings and report of a multicentric collaborative study. Oral Surg Oral Med Oral Pathol Oral Radiol Endod [Internet]. 2011;112(3):349–58. DOI: https://doi.org/10.1016/j.tripleo.2011.03.021
Lin H-P, Chen H-M, Vu C-H, Yang H, Kuo R-C, Kuo Y-S, et al. Odontogenic fibroma: a clinicopathological study of 15 cases. J Formos Med Assoc [Internet]. 2011;110(1):27–35. DOI: https://doi.org/10.1016/S0929-6646(11)60005-3
Alaeddini M, Salehizadeh S, Baghaii F, Etemad-Moghadam S. A retrospective analysis of peripheral odontogenic fibroma in an Iranian population. J Oral Maxillofac Surg [Internet]. 2010;68(9):2099–103. DOI: https://doi.org/10.1016/j.joms.2009.09.098
Lu Y, Xuan M, Takata T, Wang C, He Z, Zhou Z, et al. Odontogenic tumors. A demographic study of 759 cases in a Chinese population. Oral Surg Oral Med Oral Pathol Oral Radiol Endod [Internet]. 1998;86(6):707–14. DOI: https://doi.org/10.1016/S1079-2104(98)90208-6
Kim S-G, Jang H-S. Ameloblastoma: a clinical, radiographic, and histopathologic analysis of 71 cases. Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology. Endodontology. 2001;91(6):649–53. DOI: https://doi.org/10.1067/moe.2001.114160
Butt FMA, Guthua SW, Awange DA, Dimba EAO, Macigo FG. The pattern and occurrence of ameloblastoma in adolescents treated at a university teaching hospital, in Kenya: a 13-year study. J Craniomaxillofac Surg [Internet]. 2012;40(2):e39-45. DOI: https://doi.org/10.1016/j.jcms.2011.03.011
Chrysomali E, Leventis M, Titsinides S, Kyriakopoulos V, Sklavounou A. Odontogenic tumors. J Craniofac Surg [Internet]. 2013;24(5):1521–5. DOI: https://doi.org/10.1097/SCS.0b013e3182997aaf
Do Nascimento Souza KC, Faria PR, Costa IM, Júnior A. ORAL AND MAXILLOFACIAL PATHOLOGY Editor: Alan R. Gould. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2005;99:64–70. DOI: https://doi.org/10.1016/j.tripleo.2004.07.002
Jawad SN, Abdullah BH. Ameloblastoma vs basal cell carcinoma: an immunohistochemical comparison. Ann Diagn Pathol [Internet]. 2016;25:79–84. DOI: https://doi.org/10.1016/j.anndiagpath.2016.09.015
Negi M, Puri A, Nangia R, Sepolia N. Journal of Oral Medicine, Oral Surgery, Oral Pathology and Oral Radiology.
Sam SS, Fitzpatrick SG, Bhattacharyya I, Cohen DM, Islam MN. Adenomatoid odontogenic tumor: a series of 28 cases from a biopsy service. Quintessence Int [Internet]. 2022;53(3):260–9.
Museedi O, Hameedi AT, Abdullah BH, Allawi NS, Al-Khaurri LE. Calcifying epithelial odontogenic tumour series with unique clinical and histopathological features. Oral Surg [Internet]. 2022;15(1):24–9 . DOI: https://doi.org/10.1111/ors.12640