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Background: Oral pyogenic granuloma (PG) is a clinicopathological entity that could develop due to the reaction to a variety of stimuli, such as low-grade local irritation, traumatic damage, and hormonal stimulation. There are two histopathological types of pyogenic granuloma; lobular type -capillary hemangioma (LCH) and non-lobular type; with PG,LCH has highly vascular, diffuse capillary growth while non- lobular variant mimicking granulation tissue with heavily inflammated stroma. The study aims were to review the clinical and histopathological spectrum of an oral pyogenic granuloma from different intraoral sites in order to avoid diagnostic pitfalls associated with similar morphological lesions and to determine whether lobular and non-lobular histopathological subtypes being distinct entities.
Materials and Methods: A retrospective review of eighty formalin-fixed paraffin-embedded tissue blocks (40 cases each of males and females) were retrieved from the archives of Oral & Maxillofacial Pathology at the University of Baghdad, from 1979 to 2017. According to Mills et al., criteria for lobular capillary hemangioma description, the diagnosis of each case was confirmed by the examination of Hematoxylin and Eosin stained sections by an expert pathologists.
Results:The present result revealed that patients with oral pyogenic granuloma were with age range from 12 to 59 years, with a mean of 30.57 years. Fourty nine cases (61.25%) out of eighty were of lobular pattern and 31 cases (38.7%) of non-lobular pattern type PG. The most common site of LCH was in the buccal mucosa, 12 cases (75%), while higher case numbers were observed in the 21-30 year age group. There were non-significant differences between lobular and non-lobular pattern prevalence regarding age groups and between other studied variables.
Conclusio: It has been proposed that LCH and non-LCH subtypes reflect distinct phases in the development of a single lesion, which exhibits variable degrees of proliferative, angiogenic, and inflammatory activities.
Received date: 09-09-2021
Accepted date: 10-11-2021
This work is licensed under a Creative Commons Attribution 4.0 International License.
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Kapadia SB, Heffner DK. Pitfalls in the histopathologic diagnosis of pyogenic granuloma. Eur Arch Oto-Rhino-Laryngology. 1992;249(4):195–200.
Epivatianos A, Antoniades D, Zaraboukas T, et al. Pyogenic granuloma of the oral cavity: Comparative study of its clinicopathological and immunohistochemical features. Pathol Int. 2005;55(7):391–7.
Krishnapillai R, Punnoose K, Angadi P V, et al. Oral pyogenic granuloma-a review of 215 cases in a South Indian Teaching Hospital, Karnataka, over a period of 20 years. Oral Maxillofac Surg. 2012;16(3):305–9.
Vázquez‐Martínez OT, González‐Betancourt A, Barboza‐Cerda MC, et al. Human papillomavirus type 2 associated with pyogenic granuloma in patients without clinical evidence of warts. Int J Dermatol. 2016;55(7):745–50.
Mills SE, Cooper PH, Fechner RE. Lobular capillary hemangioma: the underlying lesion of pyogenic granuloma. A study of 73 cases from the oral and nasal mucous membranes. Am J Surg Pathol. 1980;4(5):470–9.
Rezvani G, Azarpira N, Bita G, et al. Proliferative activity in oral pyogenic granuloma: a comparative immunohistochemical study. Indian J Pathol Microbiol. 2010;53(3):403.
Kadeh H, Saravani S, Tajik M. Reactive hyperplastic lesions of the oral cavity. Iran J Otorhinolaryngol. 2015;27(79):137–44.
Graham RM. Pyogenic granuloma: an unusual presentation. Dent Update. 1996;23(6):240–1.
Agel M, Ahluwalia M. Unusual Presentation of a Pyogenic Granuloma in a 6-Year-Old Child. Dent Update. 2020;47(2):149–52.
Toida M, Hasegawa T, Watanabe F, et al. Lobular capillary hemangioma of the oral mucosa: Clinicopathological study of 43 cases with a special reference to the immunohistochemical characterization of the vascular elements. Pathol Int. 2003;53(1):1–7.
Al-Noaman AS. Pyogenic granuloma: Clinicopathological and treatment scenario. J Indian Soc Periodontol. 2020;24(3):233.
Harris MN, Desai R, Chuang TY, et al. Lobular capillary hemangiomas: An epidemiologic report, with emphasis on cutaneous lesions. J Am Acad Dermatol. 2000;42(6):1012–6.
Isaza-Guzmán DM, Teller-Carrero CB, Laberry-Bermúdez MP,et al. Assessment of clinicopathological characteristics and immunoexpression of COX-2 and IL-10 in oral pyogenic granuloma. Arch Oral Biol [Internet]. 2012 May;57(5):503–12. Available from: https://linkinghub.elsevier.com/retrieve/pii/S0003996911003827
Fortna RR, Junkins-Hopkins JM. A case of lobular capillary hemangioma (pyogenic granuloma), localized to the subcutaneous tissue, and a review of the literature. Am J Dermatopathol. 2007;29(4):408–11.
Stagner AM, Jakobiec FA. A Critical Analysis of Eleven Periocular Lobular Capillary Hemangiomas in Adults. Am J Ophthalmol [Internet]. 2016;165:164–73. Available from: http://dx.doi.org/10.1016/j.ajo.2016.03.010
Parajuli R, Maharjan S. Unusual presentation of oral pyogenic granulomas: a review of two cases. Clin Case Reports. 2018;6(4):690–3.