Diagnostic biomarkers for periodontitis (observational case-control study)

Main Article Content

Ayat Mohammed
Raghad Fadhil
https://orcid.org/0000-0002-3750-4611
Maha Sh Mahmood
Haider A Al-Waeli

Abstract

Background: Early detection of periodontal tissue loss prevents further development and halts additional damage.  The purpose of this study was to investigate the diagnostic ability of salivary Pyridinoline cross-linked carboxy-terminal telopeptide of type I collagen (ICTP) and deoxypyridinoline (DPD) in differentiating periodontitis from periodontal health. Material and method: A case-control included 80 participants who were divided into two groups: 40 periodontitis patients and 40 subjects with a healthy periodontium. Salivary samples were collected from each patient, followed by a clinical examination. The collected saliva samples were centrifuged and frozen at -80⁰C until analysis using Enzyme-Linked Immunosorbent Assay. Results: the results indicated that both biomarkers were effective in diagnosis  periodontitis. The area under the curve (AUC) for ICTP was 0.99 and the proposed cut-off point was 6.6 ng/ml, while for DPD the AUC was 0.95 and the proposed cut-off point was 211.5 nmol/L. Conclusion: Salivary ICTP and DPD demonstrated diagnostic ability in distinguishing periodontitis from a healthy periodontium, making them valuable tools in early detection and management of periodontal diseases.

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Research Articles

Author Biographies

Ayat Mohammed, Department of Periodontics, College of Dentistry, University of Baghdad, 1417, Iraq

Department of Periodontics, College of Dentistry, University of Baghdad, 1417, Iraq

Raghad Fadhil, Department of Periodontics, College of Dentistry, University of Baghdad, 1417, Iraq.

Department of Periodontics, College of Dentistry, University of Baghdad, 1417, Iraq.

Maha Sh Mahmood, Department of Periodontics, College of Dentistry, University of Baghdad, 1417, Iraq.

Department of Periodontics, College of Dentistry, University of Baghdad, 1417, Iraq.

Haider A Al-Waeli, Assistant director of the graduate periodontics Program, Dalhousie University, Canada.

Assistant director of the graduate periodontics Program, Dalhousie University, Canada.  

How to Cite

1.
Mohammed A, Fadhil R, Mahmood MS, Al-Waeli HA. Diagnostic biomarkers for periodontitis (observational case-control study). J Bagh Coll Dent [Internet]. 2024 Jun. 15 [cited 2024 Dec. 22];36(2):11-9. Available from: https://jbcd.uobaghdad.edu.iq/index.php/jbcd/article/view/3673

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