Effect of melatonin supplementation on the gingival health and lipid profiles in obese periodontitis patients

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Published: 2022-03-15
DOI: https://doi.org/10.26477/jbcd.v34i1.3092
Keywords:
melatonin, lipid profile, obese periodontitis patients.

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Hussam Sami Ismail
Master student, B.D.S, Department of Periodontics, College of Dentistry, University of Baghdad
Maha Sh. Mahmood
Professor, B.D.S., M.Sc. Department of Periodontics, College of Dentistry, University of Baghdad.

Abstract

Background: Obesity increases the host’s susceptibility by modulating the immune and inflammatory systems in a manner that predisposes to inflammatory tissue destruction and leaves an individual at greater risk of periodontitis. Melatonin is a pineal secretory product involved in numerous actions, such as regulation of internal biological clocks and energy metabolism, and it functions as an antioxidant and anti-inflammatory agent. There exists a substantial amount of evidence supporting the beneficial effect of melatonin supplementation on obesity and its complications. Aim of the study: To investigate the effects of systemic melatonin intake on periodontal health status and lipid profiles in obese periodontitis patients. Subjects and methods: Subjects included in the study were distributed into the following groups: Group I, 20 subjects with normal weight and healthy periodontium (controls) not subjected to any treatment. Group II: 30 obese periodontitis patients subjected to scaling and root planing (SRP) only. Group III: 30 obese periodontitis patients subjected to SRP and supplemented with 5mg melatonin tablets for 1 month. Study groups subjected to estimation of plaque index (PLI), bleeding on probing (BOP), cholesterol (chol), triglycerides (TG), high-density lipoprotein (HDL) and low-density lipoprotein (LDL) at baseline and after 4 weeks recall visit. Results: Regarding the clinical parameters, the second visit exhibited decreasing in all parameters in both study groups except BOP score 0 were it increased significantly. Regarding lipid profiles, the second visit showed decreasing in all profiles except HDL where it increased in both study groups with a significant difference. All correlations between lipid profiles in recall visit in both study groups exhibited a positive significant correlation between chol and TG, chol and LDL, LDL and TG in group III. In group II all results exhibited a positive significant correlation, whereas the only strong negative correlation was found between chol and HDL, HDL and LDL. Conclusion: Daily supplementation with 5mg melatonin tab significantly improved periodontal health and reduced chol, TG, LDL with increasing HDL.

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Issue

Vol. 34 No. 1 (2022)

Section

Research Articles
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How to Cite

1.
Ismail HS, Mahmood MS. Effect of melatonin supplementation on the gingival health and lipid profiles in obese periodontitis patients . J Bagh Coll Dent [Internet]. 2022 Mar. 15 [cited 2024 Dec. 22];34(1):51-9. Available from: https://jbcd.uobaghdad.edu.iq/index.php/jbcd/article/view/3092
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