Assessment of the salivary level of glutathione and the feeding pattern in molar incisor hypomineralization among 7-9 years of age: an analytical cross-sectional study
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Background: The study aimed to assess salivary glutathione levels and the pattern of feeding on molar incisor hypomineralization among healthy children aged 7-9 years. Materials and Methods: The study was a cross-sectional study. A total of 90 children sample was further sub classified into two groups: the study group, including 60 children with molar incisor hypomineralization, classified into two subgroups, 30 children with mild type and 30 children with severe type of molar incisor hypomineralization. In addition to the control group involving 30 children without incisor hypomineralization and free of caries. Examination and diagnostic criteria for hypominerlization of the molar incisor and assessment of severity were according to European Academy of Pediatric Dentistry (EAPD) guidelines in 2003. The salivary glutathione ELISA kit was used to assess the amount of glutathione in unstimulated saliva samples. After an oral examination, the parents of each child completed a self-administered questionnaire that included information on the child's feeding pattern during the first year of life. The questionnaires were returned to the researcher the following day. The child who received a mixed feeding pattern was excluded from the study. Results: The ordinal logistic regression model (Overall model test: p < 0.001) presented that salivary glutathione (p < 0.001), saliva pH (p = 0.014) and saliva flow rate (p = 0.009) were significant predictors of hypomineralization of the molar incisor. The feeding pattern (p = 0.625) and gender (p = 0.394) were not significant predicators for hypomineralization of the molar incisor hypomineralization. Conclusion: In children aged 7 to 9 years, salivary glutathione level is a negative predicator for the degree of hypomineralization of the molar incisor. Moreover, child feeding pattern, and gender, are not significant predicators of hypomineralization of the incisor hypomineralization.
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References
Rodd HD, Graham A, Tajmehr N, Timms L, Hasmun N. Molar Incisor Hypomineralisation: Current Knowledge and Practice. Int Dent J. 2021;71(4):285-291.
Garot E , Rouas P , Somani C, Taylor GD, Wong F, Lygidakis NA. An update of the aetiological factors involved in molar incisor hypomineralisation (MIH): a systematic review and meta-analysis. Eur Arch Paediatr Dent Off J Eur Acad Paediatr Dent. 2022;23(1):23-38.
Papageorgiou SN, van Waes H. Prophylaxis and Desensitizing of MIH Teeth. Molar Inci-sor Hypomineralization. Springer; 2020:113-125.
Abdalla HE, Abuaffan AH, Kemoli AM. Molar incisor hypomineralization, prevalence, pattern and distribution in Sudanese children. BMC Oral Health 2021;21(1): 9.
Weerheijm KL. Molar incisor hypomineralization (MIH): clinical presentation, aetiology and management. Dent Update. 2004;31(1):9-12.
Binti Badlishah Sham NI, Grant MM. Role of Glutathione in Neutrophil Chemotaxis in Periodontitis. Oral. 2023;3(4):526-538.
Rezazadeh F, Mahdavi D , Fassihi N , Sedarat H, Tayebi Khorami E, Tabesh A. Evaluation of the salivary level of glutathione reductase, catalase and free thiol in patients with oral lichen planus. BMC Oral Health 2023;23(1):547.
Ngamchuea K, Batchelor-McAuley C, Williams C, Godlewska BR, Sharpley AL, Cowen PJ, et al. Salivary glutathione in bipolar disorder: A pilot study. J Affect Disord. 2018;238:277-280.
Oztürk LK, Furuncuoğlu H, Atala MH, Uluköylü O, Akyüz S, Yarat A. Association between dental-oral health in young adults and salivary glutathione, lipid peroxidation and sialic acid levels and carbonic anhydrase activity. Brazilian J Med Biol Res = Rev Bras Pesqui medicas e Biol. 2008;41(11):956-959.
Salem K, Aziz D, Asadi M. Prevalence and Predictors of Molar Incisor Hypomineralization (MIH) among Rural Children in Northern Iran. Iran J Public Health. 2016;45(11):1528-1530.
Reed MC., Thomas RL, Pavisic J, Jill James S, Ulrich CM, Frederik NH. A mathematical model of glutathione metabolism. Theor Biol. Med. Model. 2008;5:1-6.
Khazaei Y, Harris CP, Heinrich J, Standl M, Kühnisch J. Association Study on Nutrition in the First Year of Life and Molar-Incisor Hypomineralization (MIH)-Results from the GINIplus and LISA Birth Cohort Studies. Int J Environ Res Public Health. 2021;18(21):11411.
Hassan DHM, Al-joranii SM. Effect of Feeding Pattern and Salivary Level of Growth Hormone on the Stage of Primary Tooth Eruption: An Analytical Cross-Sectional Study. Dent Hypotheses 2023;14(2):52-4.
Ghanim A, Elfrink M, Weerheijm K, Mariño R, Manton D. A practical method for use in epidemiological studies on enamel hypomineralisation. Eur Arch Paediatr Dent Off J Eur Acad Paediatr Dent. 2015;16(3):235-246.
Mohammed HA, Abdulkareem AA, Zardawi FM, Gul SS. Determination of the Accuracy of Salivary Biomarkers for Periodontal Diagnosis. Diagnostics (Basel, Switzerland). 2022;12(10):2485.
Navazesh M, Kumar SKS. Measuring salivary flow: challenges and opportunities. J Am Dent Assoc. 2008;139 Suppl:35S-40S.
Wu X, Wang J, Li Y, Yang Z, Zhou Z. Association of molar incisor hypomineralization with prem-aturebirthorlowbirthweight:systematicre-view and meta-analysis. J Mat Fetal Neonatal Med. 2020;33(10):1700-1708.
Silva MJ, Scurrah KJ, Craig JM, Manton DJ, Kilpatrick N. Etiology of molar incisor hypomineralization - A systematic review. Community Dent Oral Epidemiol. 2016;44(4):342-353.
Alhowaish L, Baidas L, Aldhubaiban M, Bello LL, Al-Hammad N. Etiology of molar-incisor hypo-mineralization (MIH): A cross-sectional study of Saudi children. Children. 2021 Jun 2;8(6):466.
Fatturi AL, Wambier LM, Chibinski AC, Assunção LR, Brancher JA, Reis A, et al. A systematic review and meta-analysis of systemic exposure associated with molar incisor hypomineralization. Community Dent Oral Epidemiol. 2019;47(5):407-415.
Xu Y, Zhang Y, Zheng J, Xu M, Yang Y, Guo W. ROS-Mediated Enamel Formation Disturbance Characterized by Alternative Cervical Loop Cell Proliferation and Downregulation of RhoA/ROCK in Ameloblasts. Oxid Med Cell Longev. 2022;2022:5769679.
Allazzam SM, Alaki SM, El Meligy OAS. Molar incisor hypomineralization, prevalence, and etiology. Int J Dent. 2014;2014:234508.
Ofi WA, Salih BA. Prevalence and severity of molar-incisor hypomineralisation with relation to its etiological factors among school children 7- 9 years of Al-Najaf governorate. J Bagh Coll Dent. 2015;27(3):169-173.
Salih BA, Khalaf MS. Prevalence of molar-incisor-hypomineralization among children attending pedodontic clinic of college of dentistry at Baghdad University. J bagh Coll Dent. 2012;24(4):121-5.
Hali H, Molania Jelodar T, Emadian M, Gohardehi S, Moosazadeh M, Salehi M. Prevalence of Molar Incisor Hypomineralisation among School Children of Sari, Iran. Int J Pediatr. 2021;9(9):14341-14347.
Ismail DY, Saleem SS. Prevalence of molar incisor hypomineralization (MIH) and its association with some risk factors in group of children attending two specialized dental centers in Erbil city. EDJ. 2024];6(1):83-95.
Samuel A, Asokan S, Geethapriya PR.. Caries Status and Salivary Characteristics of South Indian School Children with Molar Incisor Hypomineralization: A Cross-sectional Study. J Indian Assoc Public Health Dent 15(2):135-139,