Evaluation of the anti-bacterial effect of quercitrin in comparison with chlorhexidine in dental implants: an in vitro study
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Abstract
Background: Dental implants have been used to replace lost teeth over the past ten years because of their high success rate. Studies have shown that both Gram-positive and Gram-negative bacteria can colonize and form biofilms on the surface of an implant. Chlorhexidine acts on the inner cytoplasmic membrane to reduce plaque accumulation, making it an antiplaque and antigingivitis agent. The current study aims at elucidating and comparing Quercitrin with the well-known antibacterial chlorhexidine in their antibacterial ability to improve the dental implant procedure. Materials and methods: From each primary positive culture on blood, UTI chromogenic agar, and Mannitol salt agar media, a single colony was taken and identified, stained with Gram's stain, and examined under a light microscope. Results: The results revealed that the minimum bactericidal concentration (MBC) and the minimum inhibition concentration (MIC) of chlorohexidine were the same as 3.12 µg/mL for all isolated bacteria that have been used in this study, which was the lowest concentration used that showed a statistically significant difference. The MIC of Quercitrin for the bacteria Streptococcus. mutans, S. aureus, and P. gingivalis was 1600 µg.ml-1 and 800 µg.ml-1 for the E. faecalis, while the MBC for S. mutans, S. aureus, and P. gingivalis was 3200 µg.ml-1 and for the E. faecalis was 1600 µg.ml-1. Conclusion: In comparison with chlorhexidine, Quercitrin in a certain concentration has the same antibacterial effect, which could be a novel discovery to be used as a part of the dental implant industry as a peri-implant’s vital item for inflammation's control and prevention.
Received date: 28-02-2024
Accepted date: 10-04-2024
Published date: 15-06-2025
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