Impact of nutrient deficiencies on early childhood caries: A case-control study on Vitamin D, Calcium, and Ferritin serum levels
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Abstract
Background: Early Childhood Caries, often prompts healthcare professionals to focus on local factors, often neglecting systemic contributors. Therefore, research was designed to examine the relationships between blood levels of vitamin D, calcium, ferritin and the occurrence of Early Childhood Caries. Materials and Methods: This case‒control study included a cohort of fifty Egyptian children aged 2 to 6 years who were segregated into two equal groups: the case group (Early Childhood Caries) and the control group (free from caries). Blood samples were taken from all participants to determine the levels of vitamin D, calcium, and ferritin. Results: In terms of vitamin D levels, 24% (n=6) of the control group had insufficient vitamin D levels (10 - <30 ng/mL) compared to 88% (n = 22) of the case group (p<0.001). Regarding calcium levels, the mean calcium level was slightly higher in the case group (9.62 ± 0.39) than in the control group (9.41 ± 0.59). with no significant difference (p > 0.05). The mean ferritin level was significantly higher in the control group (79.91 ± 49.48) than in the case group (27.72 ± 7.90) (p < 0.001). Conclusion: This research shows a link between vitamin D and ferritin levels and the occurrence of Early Childhood Caries. However, no such association was seen with calcium levels.
Received date: 20-08-2024
Accepted date: 18-11-2024
Published date: 15-12-2024
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References
Alazmah A. Early childhood caries: a review. J Contemp Dent Pract. 2017;18(8):732-737.
James SL, Abate D, Abate KH, Abay SM, Abbafati C, Abbasi N et al. Global, regional, and national incidence, prevalence, and years lived with disability for 354 diseases and injuries for 195 countries and territories, 1990–2017: a systematic analysis for the Global Burden of Disease Study 2017. Lancet. 2018;392(10159):1789-1858.
Chen KJ, Gao SS, Duangthip D, Lo EC, Chu CH. Prevalence of early childhood caries among 5-year-old children: a systematic review. J Investig Clin Dent. 2019;10(1):12376.
Deane S, Schroth RJ, Sharma A, Rodd C. Combined deficiencies of 25-hydroxyvitamin D and anemia in preschool children with severe early childhood caries: A case‒control study. Paediatr Child Health. 2018 May;23(3): e40-e45.
Chan AKY, Tsang YC, Jiang CM, Leung KCM, Lo ECM, Chu CH. Diet, Nutrition, and Oral Health in Older Adults: A Review of the Literature. Dent. J. 2023; 11: 222.
Tungare S, Paranjpe AG. Diet and Nutrition to Prevent Dental Problems; Updated: 10th July 2023; Tungare S, Paranjpe AG, Eds.; StatPearls Publishing: Treasure Island, FL, USA, 2023.
Keyes PH. Research in dental caries. JADA. 1968; 76: 1357–73.
Moynihan PJ. The relationship between nutrition and systemic and oral well-being in older people. JADA. 2007;138: 493–97.
Peponis M, Antoniadou M, Pappa E, Rahiotis C, Varzakas T. Vitamin D and Vitamin D Receptor Polymorphisms Relationship to Risk Level of Dental Caries. Appl. Sci. 2023;13: 6014.
Dimaisip-Nabuab J, Duijster D, Benzian H, Heinrich-Weltzien R, Homsavath A, Monse B et al. Nutritional status, dental caries and tooth eruption in children: a longitudinal study in Cambodia, Indonesia and Lao PDR. BMC Pediatr. 2018 Sep 14;18(1):300.
Li LW, Wong HM, Peng SM, McGrath CP. Anthropometric measurements, and dental caries in children: a systematic review of longitudinal studies. Adv Nutr. 2015;6(1):52-63.
Janakiram C, Antony B, Joseph J. Association of undernutrition and early childhood dental caries. Indian Pediatr. 2018:55(8): 683-85.
Singh A, Purohit BM. Malnutrition, and its association with dental caries in the primary and permanent dentition: a systematic review and meta-analysis. Pediatr Dent. 2020;42(6):418-26.
El Shiekh MA, Hanafy RMH. Relationship between vitamin D status and caries experience in a group of Egyptian children: a cross-sectional study. BMC Oral Health. 2023 Jun 9;23(1):374.
Mobarak EH, Shabayek MM, Mulder J, Reda AH, Frencken JE. Caries experience of Egyptian adolescents: does the atraumatic restorative treatment approach offer a solution? Med Princ Pract. 2011;20(6):545-9.
Jokić NI, Bakarcić D, Janković S, Malatestinić G, Dabo J, Majstorović M, et al. Dental caries experience in Croatian school children in Primorsko-Goranska county. Cent Eur J Public Health. 2013 Mar;21(1):39-42.
Petersen, Poul Erik, Baez, Ramon J & World Health Organization. (2013). Oral health surveys: basic methods, 5th ed. World Health Organization.
WHO Guidelines on Drawing Blood: Best Practices in Phlebotomy. Geneva: World Health Organization; 2010.
Vaught JB. Blood collection, shipment, processing, and storage. Cancer Epidemiol Biomarkers Prev. 2006 Sep 1;15(9):1582-4.
Williams TL, Boyle J, Mittermuller BA, Carrico C, Schroth RJ. Association between vitamin D and dental caries in a sample of Canadian and American preschool-aged children. Nutrients. 2021;13(12):4465.
Chen Z, Lv X, Hu W, Qian X, Wu T, Zhu Y. Vitamin D status and its influence on the Health of Preschool Children in Hangzhou. Front Public Health. 2021; 9:675403.
Schroth RJ, Christensen J, Morris M, Gregory P, Mittermuller BA, Rockman-Greenberg C. The influence of prenatal vitamin D supplementation on Dental Caries in Infants. J Can Dent Assoc. 2020;86: k13.
Durá-Travé T, Gallinas-Victoriano F. Dental caries in children and vitamin D deficiency: a narrative review. Eur J Pediatr 183, 523–528 (2024).
Kim IJ, Lee HS, Ju HJ, Na JY, Oh HW. A cross-sectional study on the association between vitamin D levels and caries in the permanent dentition of Korean children. BMC Oral Health. 2018;18(1):43.
Navarro CLA, Grgic O, Trajanoska K, van der Tas JT, Rivadeneira F, Wolvius EB et al. Associations between prenatal, perinatal, and early childhood vitamin D status and risk of dental caries at 6 years. J Nutr. 2021;151(7):1993–2000.
Marques APF, Messer LB. Nutrient intake and dental caries in the primary dentition. Pediatr Dent. 1992; 14: 314-21.
Rugg-Gunn AJ, Hackett AF, Appleton DR, Jenkins GN, Eastoe JE. Relationship between dietary habits and caries increment assessed over two years in 405 English adolescent school children. Arch Oral Biol 1984; 29: 983-92.
Jha A, Jha S, Shree R, Kumar A, Menka K, Shrikaar M. Association between Serum Ferritin, Hemoglobin, Vitamin D3, Serum Albumin, Calcium, Thyrotropin-releasing Hormone with Early Childhood Caries: A Case‒Control Study. Int J Clin Pediatr Dent. 2021 Sep-Oct;14(5):648-51.
Schroth RJ, Levi JA, Sellers EA, Friel J, Kliewer E, Moffatt ME. Vitamin D Status of Children with Severe Early Childhood Caries: A Case‒control Study. BMC Pediatrics. 2013; 13: 174.
Colak H, Dülgergil CT, Dalli M, Hamidi MM. Early childhood caries update: A review of causes, diagnoses, and treatments. J Nat Sci Biol Med. 2013 Jan;4(1):29-38.
Shaoul R, Gaitini L, Kharouba J, Darawshi G, Maor I, Somri M. The association of childhood iron deficiency anemia with severe dental caries. Acta Paediatr. 2012; 101: e76-9.
Schroth RJ, Levi J, Kliewer E, Friel J, Moffatt ME. Association between iron status, iron deficiency anemia, and severe early childhood caries: a case‒control study. BMC Pediatr. 2013; 13: 22.