Serum ferritin level and B12 in a sample of Iraqi re-current aphthous stomatitis patients
Main Article Content
Abstract
Background: Recurrent aphthous stomatitis (RAS) is one of the most common oral mucosal disorders with a prevalence of 50-66%. The prevalence of hematinic deficiencies including ferritin and vitamin B12 deficiencies and their role in the prophylaxis and development of RAS is not well known. Many studies have demonstrated a high prevalence of hematinic deficiencies in patients with RAS. This study aimed to compare the serum level of ferritin and vitamin B12 in patients with recurrent aphthous ulcers and healthy controls. Subjects, Materials and Methods: The data were collected from patients who needed blood analysis to exclude anemia from November 2020 to May 2021. The study was approved by the institutional ethics committee. After recording patients' demographics ( age, gender, occupation, address) 5ml of blood was drawn from patients and controls in educational laboratories centrifuged at 3000 rpm for 10 minutes, then serum was stored at -20°C till the time of assessment of both serum ferritin and vitamin B12. The data were expressed as Mean ± SD. Students Unpaired t-test was used for comparing biochemical parameters between patients and controls and a p-value of <0.05 was considered as a statistically significant while a p-value of<0.001 was considered highly statistically significant. Results: A total of 30 RAS patients and 30 healthy control with age and gender matches were included. In the present study statistically, significant differences were observed in the serum level of ferritin and vitamin B12 between the two groups, 40% of the patients had low serum ferritin levels and 56.6 % of the patients had low serum vitamin B12 levels. Conclusion: Measuring serum ferritin and vitamin B12 levels are necessary for patients with recurrent aphthous stomatitis. It is also important for recurrent aphthous ulcer patients to have a nutritional diet containing iron and vitamin B12 to prevent the recurrence of aphthous ulceration
Received date: 13-12-2021
Accepted date: 14-01-2022
Downloads
Article Details
This work is licensed under a Creative Commons Attribution 4.0 International License.
Licenses and Copyright
The following policy applies in The Journal of Baghdad College of Dentistry (JBCD):
# JBCD applies the Creative Commons Attribution (CC BY) license to articles and other works we publish. If you submit your paper for publication by JBCD, you agree to have the CC BY license applied to your work. Under this Open Access license, you as the author agree that anyone can reuse your article in whole or part for any purpose, for free, even for commercial purposes. Anyone may copy, distribute, or reuse the content as long as the author and original source are properly cited. This facilitates freedom in re-use and also ensures that JBCD content can be mined without barriers for the needs of research.
# If your manuscript contains content such as photos, images, figures, tables, audio files, videos, etc., that you or your co-authors do not own, we will require you to provide us with proof that the owner of that content (a) has given you written permission to use it, and (b) has approved of the CC BY license being applied to their content. We provide a form you can use to ask for and obtain permission from the owner. If you do not have owner permission, we will ask you to remove that content and/or replace it with other content that you own or have such permission to use.Don't assume that you can use any content you find on the Internet, or that the content is fair game just because it isn't clear who the owner is or what license applies.
# Many authors assume that if they previously published a paper through another publisher, they own the rights to that content and they can freely use that content in their paper, but that’s not necessarily the case, it depends on the license that covers the other paper. Some publishers allow free and unrestricted re-use of article content they own, such as under the CC BY license. Other publishers use licenses that allow re-use only if the same license is applied by the person or publisher re-using the content. If the paper was published under a CC BY license or another license that allows free and unrestricted use, you may use the content in your JBCD paper provided that you give proper attribution, as explained above.If the content was published under a more restrictive license, you must ascertain what rights you have under that license. At a minimum, review the license to make sure you can use the content. Contact that JBCD if you have any questions about the license. If the license does not permit you to use the content in a paper that will be covered by an unrestricted license, you must obtain written permission from the publisher to use the content in your JBCD paper. Please do not include any content in your JBCD paper which you do not have rights to use, and always give proper attribution.
# If any relevant accompanying data is submitted to repositories with stated licensing policies, the policies should not be more restrictive than CC BY.
# JBCD reserves the right to remove any photos, captures, images, figures, tables, illustrations, audio and video files, and the like, from any paper, whether before or after publication, if we have reason to believe that the content was included in your paper without permission from the owner of the content.
How to Cite
Publication Dates
References
Ujević A, Lugović-Mihić L, Situm M, Ljubesić L, Mihić J, Troskot N. Aphthous ulcers as a multifactorial problem. Acta Clin Croat. 2013;52:213-21.
Tarakji B, Gazal G, Al-Maweri SA, Azzeghaiby SN, Alaizari N. Guideline for the diagnosis and treatment of recurrent aphthous stomatitis for dental practitioners. J Int Oral Health. 2015;7:74-80.
Moin Sabeer Tidgundi , Khaja Moinuddin, , Mirza Sharif Ahmed Baig. Ferritin and vitamin b12 levels in patients with recurrent aphthous ulcers. International Journal of Clinical Biochemistry and Research, April-June 2017;4(2):136-139.
Fischman SL. Oral ulcerations. Semin Dermatol 1994;13(2):74-7.
Koybasi S, Parlak AH, Serin E, et al. Recurrent aphthous stomatitis: Investigation of possible etiologic factors. Am J Otolaryngol 2006;27(4):229-32. DOI: https://doi.org/10.1016/j.amjoto.2005.09.022
Carrozzo M, Bone MC, Gandolfo S. Recurrent aphthous stomatitis: current etiopathogenetic and therapeutic concepts. Minerva Stomatol 1995;44(10):467-75.
Challacombe SJ, Scully C, Keevil B et al. Serum ferritin in recurrent oral ulceration. J Oral Pathol. 1983;12(4):290-9. DOI: https://doi.org/10.1111/j.1600-0714.1983.tb00339.x
Porter SR, Scully C, Flint SR, et al. Haematological status in recurrent aphthous stomatitis compared with other oral disease. Oral Surg Oral Med Oral Pathol 1988;66(1):41-4. DOI: https://doi.org/10.1016/0030-4220(88)90064-3
Field EA, Rotter E, Speechley JA, Tyldesley WR. Clinical and haematological assessment of children with recurrent aphthous ulceration. Br Dent J 1987;163(11):19-22. DOI: https://doi.org/10.1038/sj.bdj.4806174
Wang W, Knovich MA, Coffman LG, Torti FM, Torti SV ."Serum ferritin: Past, present and future" Biochimica et Bio-physica Acta (BBA) 2010 Aug;1800 (8): 760–9. DOI: https://doi.org/10.1016/j.bbagen.2010.03.011
Green, R. & Miller, J. W. in Handbook of Vitamins 5th edn (eds Zempleni, J. et al.) 447–489 (Taylor & Francis, 2014). A comprehensive review of B12 biochemistry, nutrition and metabolism.
Natah SS, Konttinen YT, Enattah NS, Ashammakhi N, Sharkey KA, Hayrinen-Immonen R. Recurrent aphthous ulcers today: a review of the growing knowledge. Int J Oral Maxillofac Implants 2004;33(3):221-34. DOI: https://doi.org/10.1006/ijom.2002.0446
Sumathi K, Shanthi B, Subha Palaneeswari M, Manjula Devi A.J. Significance of Ferritin in Recurrent Oral Ulceration. J Clin Diagn Res 2014;8(3):14-15.
Nabiha Farasat Khan, Mohammad Saeed, Saima Chaudhary, et al. Haematological Parameters and Recurrent Aphthous Stomatitis. Journal of the college of Physicians and Surgeons Pakistan 2013;23(2):124-7.
Farkhanda Ghafoor , Ayyaz A Kha. Association of Vitamin B12, Serum Ferritin and Folate Levels with Recurrent Oral Ulceration. Pak J Med Res 2012; 51 (4):132-135.
Rogers RS, Hutton KP. Screening for haematinic deficiencies in patients with recurrent aphthous stomatitis. Aust I Derm 1986;27(3):98-103. DOI: https://doi.org/10.1111/j.1440-0960.1986.tb00302.x
Volkov I, Press Y, Rudoy I. Vitamin B12 could be a “Master Key” in the regulation of multiple pathological processes. J Nippon Med Sch 2006;73(2):65-9. DOI: https://doi.org/10.1272/jnms.73.65
Thongprasom K, Youngnak P, Aneksuk V. Hematologic abnormalities in recurrent oral ulceration. South Asian J Trop Med Public Health 2002; 33: 872-7.
Wary D, Ferguson MM, Hutcheon WA, Dagg JH. Nutritional deficiencies in recurrent aphthae. J Oral Pathol 1978;7:418-23. DOI: https://doi.org/10.1111/j.1600-0714.1978.tb01612.x
Olson JA, Feinberg I, Silverman S Jr, Abrams D, Greenspan JS. Oral Surg Oral Med Oral Pathol 1982; 54: 571-20. DOI: https://doi.org/10.1016/0030-4220(82)90189-X
Nolan A, Lamey PJ, Milligan KA, Forsyth A. Recurrent aphthous ulceration and food sensitivity. J Oral Pathol Med 1991;20(10):473-5. DOI: https://doi.org/10.1111/j.1600-0714.1991.tb00406.x
Weusten Bl, Van De Wiel A. Aphthous ulcers and vit B12 deficiency. Neth J Med 1998;53:172-5. DOI: https://doi.org/10.1016/S0300-2977(98)00096-5
Burgan SZ, Sawair FA, Amarin ZO. Hematologic status in patients with recurrent aphthous stomatitis in Jordan. Saudi Med J. 2006; 27: 381-4.
Piskin S, Sayan C, Durukan N, Senol M. Serum iron, ferritin, folic acid, and vitamin B12 levels in recurrent aphthous stomatitis. J Eur Acad Dermatol Venereol. 2002; 16:66-7. DOI: https://doi.org/10.1046/j.1468-3083.2002.00369.x
Volkov IIIA, Rudoy I, Freud T, Sardal G, Naimer S, Peleg R, et al. Effectiveness of vitamin B12 in treating recurrent aphthous stamatitis: A randomized, double blind placebo controlled trial. J Am Board Fam Med 2009; 22: 9-1. DOI: https://doi.org/10.3122/jabfm.2009.01.080113